sharing sensitive information, make sure youre on a federal Researchers in China first shared this idea in March 2020, and the findings were echoed by a paper out of Columbia University a month later. Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. First there is a reaction in the arm where you are injected - think swelling and soreness - as the immune system swings into gear. 14:1107866. doi: 10.3389/fimmu.2023.1107866. ABO blood typing was performed using a test-tube method according to the manufacturers protocol (Chengdu Xiehe Ltd., Co., Chengdu, China). These include: chills fatigue fever headache muscle pain nausea pain at the injection site redness at the. 2021 Sep 2;17(9):2957-2958. doi: 10.1080/21645515.2021.1922061. One study of over 3,000 people who got a COVID-19 vaccine did not find any increased side effects or other issues among people with different blood types. Anderson's group examined data from Intermountain Healthcare, an integrated system of 24 hospitals and 215 clinics in Utah, Idaho, and Nevada. We thank all study participants, the Henan Provincial Peoples Hospital data safety monitoring board, and the study-steering committee. The positive rate of neutralizing antibodies peaked at 97.7% at 6090 days, decreased, and stabilized at 82.9% at 181240 days post-vaccination. Interestingly, individuals with blood type A produced lower amounts of IFN- at 180240 days after vaccination and had lower neutralizing antibodies at 114 days than those with blood type B. Received: 25 November 2022; Accepted: 20 February 2023;Published: 03 March 2023. Vous pouvez modifier vos choix tout moment en cliquant sur le lien Tableau de bord sur la vie prive prsent sur nos sites et dans nos applications. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Then, a study published in the New England Journal of Medicine confirmed the idea with a peer-reviewed study: Folks with Type A blood were 45 percent more likely to become infected with Covid than those with other blood types, while those with Type O were 35 percent less likely. Therefore, we designed a multicenter, longitudinal, observational study to evaluate the immunogenicity and reactogenicity of a second dose of inactivated vaccine among those who received the two vaccines from different manufacturers. *Correspondence: Yi Li, liyilebmed@henu.edu.cn, These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all Blood clots with low platelets Capillary leak syndrome Guillain-Barr syndrome (GBS) Ongoing monitoring of side effects and reactions As the COVID-19 vaccine rollout continues across Canada, safety monitoring is ongoing. This can be a sign of anaphylaxis, a severe allergic reaction. The most frequent of them are headache, GBS, VST, and transverse myelitis. All authors contributed to the article and approved the submitted version. John Quinn is a London-based writer and editor who specializes in lifestyle topics. Acute disseminated encephalomyelitis following the COVID-19 vaccine Ad26.COV2.S, a case report. Participants in the mixed-manufacturer vaccination group, those with an interval of >40 days between doses of vaccination, and workers produced lower levels of IL-6 than those in the same-manufacturer vaccination group, those with an interval of <40 days between doses of vaccination, and medical staff (B = 0.01, 95% CI 0.014 to 0.003, p = 0.003, B = 0.44, 95% CI 0.8 to 0.1, p = 0.019, and B = 1.5, 95% CI 2.1 to 0.9, p < 0.001, respectively; Table6; Figures3FH). To our knowledge, this study is the first to report that a heterologous Chinese COVID-19 inactivated vaccine administration schedule induced humoral and cellular immune responses in humans and that it was associated with an acceptable and manageable reactogenicity profile 240 days after vaccination. The two tubes with the EDTA anticoagulant were used to determine lymphocyte subsets with or without antigen-stimulated SARS-CoV-2 spike peptides, and the two tubes without the EDTA anticoagulant were used to determine neutralizing antibodies against SARS-CoV-2 and cytokines with or without antigen-stimulated SARS-CoV-2 spike peptides. That link was established pretty early on in the pandemic and scientists didn't let it go. Cytokine levels and lymphocyte subset counts were measured using flow cytometry (Beamcyte-1026; Changzhou Beamdiag Co., Ltd., Changzhou, China). 38 Articles, This article is part of the Research Topic, https://doi.org/10.3389/fimmu.2023.1107866, https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, Creative Commons Attribution License (CC BY). doi:10.1016/j.vaccine.2020.12.083, 6. Front. We know the Covid virus damages the lining of your blood vessels. In the future, we will include more participants after administering booster vaccines and conduct pseudo-virus neutralization tests to address these limitations. The results were notable: Adjusting for demographics and co-morbidities, the risk for a COVID-19 diagnosis was 12 percent lower for people with type O blood and the risk for severe COVID-19 or death was 13 percent lower, compared to those with A, AB, or B blood types. Just because youre Type O doesnt mean youre in the clear. Wheatley AK, Juno JA, Wang JJ, Selva KJ, Reynaldi A, Tan HX, et al. ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. The levels of IFN- and CD4+ T-lymphocytes were not altered in the participants for 240 days after vaccination, whereas the levels of neutralizing antibodies, B-lymphocytes, and IL-6 decreased with increasing time after vaccination. J Clin Epidemiol (2022) 144:16372. This may be due to the increased exposure of medical staff to patients with COVID-19 compared to people in other occupations. Individuals vaccinated with different vaccines, those with blood type A, and workers had weaker humoral and cellular immune responses to vaccines than those vaccinated with the same vaccine, those with blood type B, and medical staff. These fun facts about everything from the cosmos to the inner workings of your body will blow your mind. Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, et al. Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. COVID vaccines and safety: what the research says. doi:10.1001/jama.2021.19499, 11. Nat Commun (2020) 11:5761. doi:10.1038/s41467-020-19623-x, 20. } else { 2021 Nov 15;360:577703. doi: 10.1016/j.jneuroim.2021.577703. Type O blood, the most common in the U.S., provides some protection against COVID. doi:10.1093/nsr/nwab193, 14. doi:10.1056/NEJMoa2027187, Keywords: cellular immune response, COVID-19, inactive vaccine, kinetics, neutralizing antibody, Citation: Yuan Y, Xu J, Ma B, Chen G, Wang Z, Wang S, Jing N, Zhang J, Wang B, Yan W, Zhang Q, Zhao Q and Li Y (2023) Characteristics of humoral and cellular responses to coronavirus disease 2019 (COVID-19) inactivated vaccine in central China: A prospective, multicenter, longitudinal study. Healthcare professionals, particularly neurologists involved in the management of patients having undergone SARS-CoV-2 vaccinations, should be aware of these side effects and should stay vigilant to recognize them early and treat them adequately. Would you like email updates of new search results? To address this issue, in 1991, a group of scientists in Minnesotaat the Department of Veterans Affairs and the . Opens in a new tab or window, Visit us on Facebook. People with Type O blood might be slightly more protected from the virus, and people with Type A slightly more vulnerable. YY and JX designed the study, analyzed the data, and wrote the manuscript. document.addEventListener( 'DOMContentLoaded', function() { navigator.sendBeacon('https://www.google-analytics.com/collect', payload); First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. Li JX, Wu SP, Guo XL, Tang R, Huang BY, Chen XQ, et al. "Our next study will specifically look at such antibodies, and whether they explain the protective effect," Ray told Reuters. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Both primary and safety analyses included all participants who received two doses of the inactivated vaccine and had suffered local and systemic adverse events for 30 consecutive days after vaccination. if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { Although not all of these side effects may occur, if they do occur they may need . Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). 30. Pour en savoir plus sur la faon dont nous utilisons vos donnes personnelles, veuillez consulter notre politique relative la vie prive et notre politique en matire de cookies. Borobia AM, Carcas AJ, Prez-Olmeda M, Castao L, Bertran MJ, Garca-Prez J, et al. } 20052022 MedPage Today, LLC, a Ziff Davis company. Those who are O-negative may be the least likely to get COVID. COVID-19 vaccine side effects can vary depending on a person's age, sex, or health. Occupation was another contributing factor, as the medical staff produced one-fold more neutralizing antibodies than the workers during the 1240 days after vaccination (B = 1.0, 95% CI 1.5 to 0.55; p < 0.001; Table2; Figure2D). Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). doi:10.1128/spectrum.01181-21, 21. You'll always want to stay at your vaccination site for at least 15 minutes after you get the shot (30 minutes if you've had a severe allergic reaction before). Therefore, we were able to collect data of a few individuals who had received mixed vaccinations at the time. Moderna says 9.7% of their participants felt fatigued and 4.5% got . The participants in the study (mixed-manufacturer vaccination for the two doses) and control (same-manufacturer vaccination for both doses) groups remained in local community health centers for at least 30min after vaccination to monitor safety, and the occurrence of any adverse event during this observation period was recorded. doi:10.1002/jmv.27825, 10. Vaccine induced immune thrombotic thrombocytopenia causing a severe form of cerebral venous thrombosis with high fatality rate: a case series. However, this speculation requires validation using a larger patient cohort. The discovery of Type Os protective effect is crucial to building an understanding of how the virus works. "Reassuring the public that everything is being done . Disclaimer. 2021;30(12):721146. doi:10.3389/fneur.2021.721146 But the seemingly-banal detail might be a factor in who is most susceptible to Covid 19. Therefore, the objective of this study was to evaluate the cellular immune responses and neutralizing antibody kinetics of homologous and heterologous administrations of an inactivated coronavirus disease 2019 (COVID-19) vaccine 240 days . The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, 1. Here is all the latest news about convicted killer, Alex Murdaugh. Possible side effects: Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. You experience shortness of breath or swelling of the lips or face. It is suggested that pain in the application area is the most frequent side effect among workers in a Mexican hospital who received the Pfizer BioNTech vaccine against COVID-19. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. This finding suggests that cellular immune responses lasted longer than humoral responses in the vaccinated population. Opens in a new tab or window, Share on Twitter. Among those who had COVID-19, hospitalization and ICU admission was associated with male sex and age. The log-transformed level of interferon-gamma, CD4+ T-cell count, B-lymphocyte count, and IL-6 level were used as independent variables. Researchers have been talking about blood type and COVID-19 susceptibility for months. Si vous souhaitez personnaliser vos choix, cliquez sur Grer les paramtres de confidentialit. The difference may be the type of antibodies we produce depending on blood type. government site. Table2 Factors associated with the neutralization antibody concentration after the administration of the Chinese inactivated COVID-19 vaccine. World J Clin Cases. Whether mild or severe, data from the U.S. Centers for Disease Control and Prevention (CDC), has shown that women are bearing the brunt of vaccine reactions, and experts believe it may be due to . Also, if possible, get some rest. A linear regression analysis using a mixed-effect model showed that age, vaccination mode, occupation, interval between doses of vaccination, and vaccination duration were factors significantly associated with the levels of neutralizing antibodies (Tables13; Tables S1S7). In addition, we are grateful to our colleagues Wenning Yang, Yafei Chu, Qiong Ma, and Wenbo Xu, who assisted with sample collection. Julita Mir, M.D., Infectious Disease Physician and . From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. "Blood group O is significantly associated with reduced susceptibility to SARS-CoV-2. We found that participants with a longer interval between vaccination doses (4056 days) had higher levels of neutralizing antibodies than those with a shorter interval (2140 days). However, in this study, the GMC in participants in the mixed-manufacturer group was lower than that in participants in the same-manufacturer group, which is perhaps due to the fact that vaccines from different manufacturers were still of the same type (both inactivated vaccines, but a protein or attenuated live vaccine). Reported side effects of COVID-19 vaccines have mostly been mild to moderate and have lasted no longer thana few days. eCollection 2021. According to Pfizer, about 3.8% of their clinical trial participants experienced fatigue as a side effect and 2% got a headache. Lancet Respir Med (2022) 10:73948. Fujigaki H, Yamamoto Y, Koseki T, Banno S, Ando T, Ito H, et al. Participants with a clinically notable acute illness or a body temperature of at least 38C within 24h before receiving the planned dose of the study vaccine, clinical manifestations compatible with those of COVID-19, and any condition that contraindicates or discourages the administration of an inactivated vaccine, including pregnancy, were excluded (15). Acta Neurol Scand. "It's pretty clear that Type O is protective to some degree. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. We dont know why people with Type O might possibly be more protectedbut there are a lot of theories. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. Source Reference: Anderson JL, et al "Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population" JAMA Netw Open 2021; DOI: 10.1001/jamanetworkopen.2021.7429. Prospective cohort of Chinese individuals immunized with the inactivated vaccine and serological assays. When a vaccine is injected, the body's immune response jumps into action, responding to the presence of a foreign entity. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. HHS Vulnerability Disclosure, Help For a March study out of the Southern University of Science and Technology in Shenzhen, China, scientists tracked the blood types of nearly 2,200 COVID-19 patients in Chinese hospitals, along with those of about 27,000 individuals who didn't have COVID-19 in the same areas. A retrospective analysis of clinically confirmed long post-COVID vaccination syndrome. Follow. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: A preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. But the virus is still in your system and you can still pass it to someone else.". Since both of those types are fairly rare, the Red Cross works hard to . The platelets, which normally promote wound healing, end up clumping and causing blood. Unfolding the determinants of COVID-19 vaccine acceptance in China. The most common side effect of the vaccine is temporary soreness and swelling at the injection site. afficher des publicits et des contenus personnaliss en fonction de vos profils de centres dintrt; mesurer lefficacit des publicits et contenus personnaliss; et. -, Wiedmann M, Skattr T, StrayPedersen A, et al. It varies from person to person, but how dramatic the initial response is does not necessarily relate to the long-term response. COVID-19 vaccine guidelines was numerous in quantity but many lack transparent reporting of methodological practices. Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. And guess what: People with Type A blood have higher levels of VWF naturally than people with type O blood, Dr. Udden points out. In both groups, most of the adverse events were mild (n = 25, 81.1%) or moderate (n = 6, 18.9%) and self-limited. She is a 2020 J2 Achievement Award winner for her COVID-19 coverage. Data were calculated based on a linear mixed-effects model adjusted for vaccine manufacturer, sex, age, blood type, occupation, and body mass index (BMI). Based on their data, the Novavax vaccine has a significantly lower rate of side effects compared to the Pfizer-BioNTech and Moderna vaccines. xhr.send(payload); In this study, a higher frequency of adverse events reported by participants in the mixed-manufacturer vaccination group. Serious side effects. COVID19 vaccination acceptance among healthcare workers and nonhealthcare workers in China: a survey. We may earn commission from links on this page, but we only recommend products we back. Unfortunately, this is a much more rare blood type. The most basic idea is that blood type might influence a persons ability to fight the virus, says David Aronoff, M.D., director of the division of infectious diseases at Vanderbilt University Medical Center in Nashville. Other neurological side effects occur in a much lower frequency. Science-based COVID-19 vaccine development. Epub 2022 Jun 1. Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses.